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1

Glutathione conjugation as a bioactivation reaction

Peter J van Bladeren

Journal:

Chemico-Biological Interactions

Year:

2000

Language:

english

File:

PDF, 146 KB

english, 2000

2

In Vivo and in Vitro Metabolic Studies of Furazolidone: A Risk Evaluation

Vroomen, Louis H. M., Berghmans, Marcel C. J., Van Bladeren, Peter J., Groten, John P., Wissink, C. J., Kuiper, Harry A.

Journal:

Drug Metabolism Reviews

Year:

1990

Language:

english

File:

PDF, 999 KB

english, 1990

3

Identification of a reactive intermediate of furazolidone formed by swine liver microsomes

Louis H.M. Vroomen, John P. Groten, Kees van Muiswinkel, Albertus van Velduizen, Peter J. van Bladeren

Journal:

Chemico-Biological Interactions

Year:

1987

Language:

english

File:

PDF, 700 KB

english, 1987

4

Newly constructed stable reporter cell lines for mechanistic studies on electrophile-responsive element-mediated gene expression reveal a role for flavonoid planarity

Anne-Marie J.F. Boerboom, Martijn Vermeulen, Hester van der Woude, Birgit I. Bremer, Yee Y. Lee-Hilz, Ellen Kampman, Peter J. van Bladeren, Ivonne M.C.M. Rietjens, Jac M.M.J.G. Aarts

Journal:

Biochemical Pharmacology

Year:

2006

Language:

english

File:

PDF, 281 KB

english, 2006

5

Subacute Toxicity of a Mixture of Nine Chemicals in Rats: Detecting Interactive Effects with a Fractionated Two-Level Factorial Design

John P. Groten, Eric D. Schoen, Peter J. van Bladeren, C.Frieke Kuper, Job A. van Zorge, Victor J. Feron

Journal:

Fundamental and Applied Toxicology

Year:

1997

Language:

english

File:

PDF, 136 KB

english, 1997

6

4-Week oral toxicity study of a combination of eight chemicals in rats: Comparison with the toxicity of the individual compounds

D. Jonker, R.A. Woutersen, P.J. van Bladeren, H.P. Til, V.J. Feron

Journal:

Food and Chemical Toxicology

Year:

1990

Language:

english

File:

PDF, 720 KB

english, 1990

7

Acute (24 hr) toxicity of a combination of four nephrotoxicants in rats compared with the toxicity of the individual compounds

D. Jonker, M.A. Jones, P.J. van Bladeren, R.A. Woutersen, H.P. Til, V.J. Feron

Journal:

Food and Chemical Toxicology

Year:

1993

Language:

english

File:

PDF, 717 KB

english, 1993

8

Subacute (4-wk) oral toxicity of a combination of four nephrotoxins in rats: comparison with the toxicity of the individual compounds

D. Jonker, R.A. Woutersen, P.J. Van Bladeren, H.P. Til, V.J. Feron

Journal:

Food and Chemical Toxicology

Year:

1993

Language:

english

File:

PDF, 969 KB

english, 1993

9

Subacute Toxicity of a Mixture of Nine Chemicals in Rats: Detecting Interactive Effects with a Fractionated Two-Level Factorial Design

GROTEN, JOHN P., SCHOEN, ERIC D., VAN BLADEREN, PETER J., KUPER, C. FRIEKE, VAN ZORGE, JOB A., FERON, VICTOR J.

Journal:

Toxicological Sciences

Year:

1997

Language:

english

File:

PDF, 1.21 MB

english, 1997

10

Top-down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model

Martin, Francois-Pierre J, Wang, Yulan, Sprenger, Norbert, Yap, Ivan K S, Rezzi, Serge, Ramadan, Ziad, Peré-Trepat, Emma, Rochat, Florence, Cherbut, Christine, van Bladeren, Peter, Fay, Laurent B, Koc

Journal:

Molecular Systems Biology

Year:

2008

Language:

english

File:

PDF, 647 KB

english, 2008

11

Identification of multiple target sites for a glutathione conjugate on glutathione-S-transferase by matrix-assisted laser desorption/ionization mass spectrometry

Jespersen, S., Ploemen, J. H. T. M., van Bladeren, P. J., Niessen, W. M. A., Tjaden, U. R., van der Greef, J.

Journal:

Journal of Mass Spectrometry

Year:

1996

Language:

english

File:

PDF, 576 KB

english, 1996

12

Interaction of hesperetin glucuronide conjugates with human BCRP, MRP2 and MRP3 as detected in membrane vesicles of overexpressing baculovirus-infected Sf9 cells

Walter Brand, Berend Oosterhuis, Peter Krajcsi, Denis Barron, Fabiola Dionisi, Peter J. van Bladeren, Ivonne M. C. M. Rietjens, Gary Williamson

Journal:

Biopharmaceutics & Drug Disposition

Year:

2011

Language:

english

File:

PDF, 215 KB

english, 2011

13

Electron impact and chemical ionization mass spectrometry of cis- and trans-S-(2-hydroxyclohexyl)-N-acetyl-(l)-cysteine methyl esters

N. P. E. Vermeulen, J. Cauvet, W. C. M. M. Luijten, P. J. van Bladeren

Journal:

Biological Mass Spectrometry = Journal of Mass Spectrometry (Wiley)

Year:

1980

Language:

english

File:

PDF, 422 KB

english, 1980

14

The effect of co-administered flavonoids on the metabolism of hesperetin and the disposition of its metabolites in Caco-2 cell monolayers

Walter Brand, Beatriz Padilla, Peter J. van Bladeren, Gary Williamson, Ivonne M. C. M. Rietjens

Journal:

Molecular Nutrition & Food Research

Year:

2010

Language:

english

File:

PDF, 303 KB

english, 2010

15

In silico methods for physiologically based biokinetic models describing bioactivation and detoxification of coumarin and estragole: Implications for risk assessment

Ivonne M. C. M. Rietjens, Ans Punt, Benoît Schilter, Gabriele Scholz, Thierry Delatour, Peter J. van Bladeren

Journal:

Molecular Nutrition & Food Research

Year:

2010

Language:

english

File:

PDF, 331 KB

english, 2010

16

Toxicology of chemical mixtures: challenges for today and the future

V.J. Feron, J.P. Groten, D. Jonker, F.R. Cassee, P.J. van Bladeren

Journal:

Year:

1995

Language:

english

File:

PDF, 1.31 MB

english, 1995

17

Transport and metabolism of glutathione conjugates of menadione and ethacrynic acid in confluent monolayers of rat renal proximal tubular cells

H.E.M.G. Haenen, A. Spenkelink, C. Teunissen, J.H.M. Temmink, J.H. Koemana, P.J. van Bladeren

Journal:

Year:

1996

Language:

english

File:

PDF, 1.13 MB

english, 1996

18

Chemical and enzyme-catalysed synthesis of quinoline arene hydrates

Rajiv Agarwal, Derek R. Boyd, Narain D. Sharma, R. Austin, S. McMordie, H.Patricia Porter, Ben van Ommen, Peter J. van Bladeren

Journal:

Bioorganic & Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 1006 KB

english, 1994

19

Genomic tools to study biological effects of food

P. van-Bladeren

Journal:

Journal of Biotechnology

Year:

2010

Language:

english

File:

PDF, 122 KB

english, 2010

20

An improved method for the separation and quantification of glutathione S-transferase subunits in rat tissue using high-performance liquid chromatography

Jan J.P. Bogaards, Ben van Ommen, Peter J. van Bladeren

Journal:

Journal of Chromatography A

Year:

1989

Language:

english

File:

PDF, 366 KB

english, 1989

21

Facile synthesis of K-region arene oxides

P.J. van Bladeren, D.M. Jerina

Journal:

Tetrahedron Letters

Year:

1983

Language:

english

File:

PDF, 257 KB

english, 1983

22

The dual role of glutathione conjugation in the biotransformation of xenobiotics. A multidisciplinary investigation

P. J. Van Bladeren

Journal:

International Journal of Clinical Pharmacy

Year:

1982

Language:

english

File:

PDF, 176 KB

english, 1982

23

Genetic deficiency of human class mu glutathione S-transferase isoenzymes in relation to the urinary excretion of the mercapturic acids of Z- and E-1,3-dichloropropene

Ria M. E. Vos, Ronald T. H. van Welie, Wilbert H. M. Peters, Chris T. A. Evelo, Jan J. P. Boogaards, Nico P. E. Vermeulen, Peter J. van Bladeren

Journal:

Archives of Toxicology

Year:

1991

Language:

english

File:

PDF, 562 KB

english, 1991

24

Militaire apothekers

D. van Bladeren

Journal:

International Journal of Clinical Pharmacy

Year:

1980

Language:

dutch

File:

PDF, 572 KB

dutch, 1980

25

Sectievergaderingen

P. H. Vree, D. Van Bladeren, H. A. Sloot, A. W. M. Indemans

Journal:

International Journal of Clinical Pharmacy

Year:

1979

Language:

dutch

File:

PDF, 1.02 MB

dutch, 1979

26

Uw patiënt rookt, wat nu?

Fleur van Bladeren, Ingrid Stevens

Journal:

Nederlands Tijdschrift voor Evidence Based Practice

Year:

2007

Language:

dutch

File:

PDF, 113 KB

dutch, 2007

27

Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer–related mechanisms in colon cancer cells in vitro

M. J. van Erk, P. Roepman, T. R. van der Lende, R. H. Stierum, J. M. M. J. G. Aarts, P. J. van Bladeren, B. van Ommen

Journal:

European Journal of Nutrition

Year:

2005

Language:

english

File:

PDF, 360 KB

english, 2005

28

Glutathione S-transferase activity and isoenzyme composition in benign ovarian tumours, untreated malignant ovarian tumours, and malignant ovarian tumours after platinum/cyclophosphamide chemotherapy

van der Zee, AGJ, van Ommen, B, Meijer, C, Hollema, H, van Bladeren, PJ, de Vries, EGE

Journal:

British Journal of Cancer

Year:

1992

Language:

english

File:

PDF, 1.29 MB

english, 1992

29

Structure−Activity Study on the Quinone/Quinone Methide Chemistry of Flavonoids

Awad, Hanem M., Boersma, Marelle G., Boeren, Sjef, van Bladeren, Peter J., Vervoort, Jacques, Rietjens, Ivonne M. C. M.

Journal:

Chemical Research in Toxicology

Year:

2001

Language:

english

File:

PDF, 127 KB

english, 2001

30

Quenching of Quercetin Quinone/Quinone Methides by Different Thiolate Scavengers: Stability and Reversibility of Conjugate Formation

Awad, Hanem M., Boersma, Marelle G., Boeren, Sjef, van Bladeren, Peter J., Vervoort, Jacques, Rietjens, Ivonne M. C. M.

Journal:

Chemical Research in Toxicology

Year:

2003

Language:

english

File:

PDF, 190 KB

english, 2003

31

Regioselectivity of Phase II Metabolism of Luteolin and Quercetin by UDP-Glucuronosyl Transferases

Boersma, Marelle G., van der Woude, Hester, Bogaards, Jan, Boeren, Sjef, Vervoort, Jacques, Cnubben, Nicole H. P., van Iersel, Marlou L. P. S., van Bladeren, Peter J., Rietjens, Ivonne M. C. M.

Journal:

Chemical Research in Toxicology

Year:

2002

Language:

english

File:

PDF, 95 KB

english, 2002

32

A state-of-the-art overview of the effect of metabolic conjugation on the biological activity of flavonoids

Beekmann, Karsten, Actis-Goretta, Lucas, van Bladeren, Peter J., Dionisi, Fabiola, Destaillats, Frederic, Rietjens, Ivonne M. C. M.

Journal:

Food & Function

Year:

2012

Language:

english

File:

PDF, 160 KB

english, 2012

33

Physiologically Based Biokinetic (PBBK) Modeling of Safrole Bioactivation and Detoxification in Humans as Compared With Rats

Martati, E., Boersma, M. G., Spenkelink, A., Khadka, D. B., van Bladeren, P. J., Rietjens, I. M. C. M., Punt, A.

Journal:

Toxicological Sciences

Year:

2012

Language:

english

File:

PDF, 2.13 MB

english, 2012

34

Tandem Mass Spectrometry Analysis of N2-(trans-Isoestragol-3‘-yl)-2‘-deoxyguanosine as a Strategy to Study Species Differences in Sulfotransferase Conversion of the Proximate Carcinogen 1‘-Hydroxyestragole

Punt, Ans, Delatour, Thierry, Scholz, Gabriele, Schilter, Benoît, van Bladeren, Peter J., Rietjens, Ivonne M. C. M.

Journal:

Chemical Research in Toxicology

Year:

2007

Language:

english

File:

PDF, 117 KB

english, 2007

35

A Physiologically Based Pharmacokinetic (PB-PK) Model for 1,2-Dichlorobenzene Linked to Two Possible Parameters of Toxicity

A.M. Hissink, B. Van Ommen, J. Krüse, P.J. Van Bladeren

Journal:

Toxicology and Applied Pharmacology

Year:

1997

Language:

english

File:

PDF, 159 KB

english, 1997

36

Species and Strain Differences in the Hepatic Cytochrome P450-Mediated Biotransformation of 1,4-Dichlorobenzene

A.M. Hissink, M.J. Oudshoorn, B. Van Ommen, P.J. Van Bladeren

Journal:

Toxicology and Applied Pharmacology

Year:

1997

Language:

english

File:

PDF, 143 KB

english, 1997

37

The microsomal metabolism of pentachlorophenol and its covalent binding to protein and DNA

Ben van Ommen, Anton Adang, Franz Müller, Peter J. van Bladeren

Journal:

Chemico-Biological Interactions

Year:

1986

Language:

english

File:

PDF, 595 KB

english, 1986

38

The role of glutathione and glutathione S-transferases in fatty acid ozonide detoxification

I.M.C.M. Rietjens, H.H. Lemmink, G.M. Alink, P.J. Van Bladeren

Journal:

Chemico-Biological Interactions

Year:

1987

Language:

english

File:

PDF, 694 KB

english, 1987

39

Differential toxicity as a result of apical and basolateral treatment of LLC-PK1 monolayers with S-(1,2,3,4,4-pentachlorobutadienyl)glutathione and N-acetyl-S-(1,2,3,4,4-pentachlorobutadienyl)-L-cysteine

Jos J.W.M. Mertens, John G.J. Weijnen, Wim J. Van Doorn, Bert Spenkelink, Johan H.M. Temmink, Peter J. Van Bladeren

Journal:

Chemico-Biological Interactions

Year:

1988

Language:

english

File:

PDF, 627 KB

english, 1988

40

The oxidation of tetrachloro-1,4-hydroquinone by microsomes and purified cytochrome P-450b. Implications for covalent binding to protein and involvement of reactive oxygen species

Ben van Ommen, Jan Willem Voncken, Franz Müller, Peter J. van Bladeren

Journal:

Chemico-Biological Interactions

Year:

1988

Language:

english

File:

PDF, 736 KB

english, 1988

41

Methyl linoleate ozonide as a substrate for rat glutathione S-transferases: Reaction pathway and isoenzyme selectivity

Ria M.E. Vos, Ivonne M.C.M. Rietjens, Luc H. Stevens, Peter J. Van Bladeren

Journal:

Chemico-Biological Interactions

Year:

1989

Language:

english

File:

PDF, 528 KB

english, 1989

42

Cytotoxicity of S-(1,2,3,4,4-pentachlorobutadienyl)-L-cysteine after apical and basolateral exposure of LLC-PK1 monolayers. Involvement of an amino acid transport system

Jos J.W.M. Mertens, Erik A.J. Keukens, Marco Appel, Bert Spenkelink, Johan H.M. Temmink, Peter J. van Bladeren

Journal:

Chemico-Biological Interactions

Year:

1990

Language:

english

File:

PDF, 663 KB

english, 1990

43

Irreversible inhibition of rat hepatic glutathione S-transferase isoenzymes by a series of structurally related quinones

Ria M.E. Vos, Ben Van Ommen, Mark S.J. Hoekstein, Jolanda H.M. De Goede, Peter J. Van Bladeren

Journal:

Chemico-Biological Interactions

Year:

1989

Language:

english

File:

PDF, 637 KB

english, 1989

44

Glutathione S-transferases in relation to their role in the biotransformation of xenobiotics

Ria M.E. Vos, Peter J. Van Bladeren

Journal:

Chemico-Biological Interactions

Year:

1990

Language:

english

File:

PDF, 1.44 MB

english, 1990

45

The involvement of primary and secondary metabolism in the covalent binding of 1,2- and 1,4-dichlorobenzenes

Cathaline den Besten, Marlies Ellenbroek, Marjan A.E. van der Ree, Ivonne M.C.M. Rietjens, Peter J. van Bladeren

Journal:

Chemico-Biological Interactions

Year:

1992

Language:

english

File:

PDF, 1.05 MB

english, 1992

46

Metabolism and biochemical effects of 3,3′,4,4′-tetrachlorobiphenyl in pregnant and fetal rats

Dennis C. Morse, Eva Klasson Wehler, Maribel van de Pas, Albert Th.H.J. de Bie, Peter J. van Bladeren, Abraham Brouwer

Journal:

Chemico-Biological Interactions

Year:

1995

Language:

english

File:

PDF, 1.22 MB

english, 1995

47

The interaction of glutathione with 4-hydroxycyclophosphamide and phosphoramide mustard, studied by 31P nuclear magnetic resonance spectroscopy

H.A.A.M. Dirven, J.C. Venekamp, B. van Ommen, P.J. van Bladeren

Journal:

Chemico-Biological Interactions

Year:

1994

Language:

english

File:

PDF, 550 KB

english, 1994

48

Comparison of the urinary metabolite profiles of hexachlorobenzene and pentachlorobenzene in the rat

Cathaline den Besten, Marjon M.H. Bennik, Marlou van Iersel, Maria A.W. Peters, Cees Teunis, Peter J. van Bladeren

Journal:

Chemico-Biological Interactions

Year:

1994

Language:

english

File:

PDF, 964 KB

english, 1994

49

In vitro metabolism of 5-fluoro-2-glutathionyl-nitrobenzene by kidney proximal tubular cells studied by 19F-NMR

H.E.M.G. Haenen, I.M.C.M. Rietjens, J. Vervoort, J.H.M. Temmink, P.J. van Bladeren

Journal:

Chemico-Biological Interactions

Year:

1995

Language:

english

File:

PDF, 951 KB

english, 1995

50

Inhibition of human glutathione S-transferases by dopamine, α-methyldopa and their 5-S-glutathionyl conjugates

Jan H.T.M. Ploemen, Ben Van Ommen, Annemarie De Haan, Joke C. Venekamp, Peter J. Van Bladeren

Journal:

Chemico-Biological Interactions

Year:

1994

Language:

english

File:

PDF, 797 KB

english, 1994

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